div{
  display: -webkit-box;
  display: -webkit-flex;
  height: 50px;
  background: #ff0000;
  color: #ffffff;
  width: 300px;
  -webkit-justify-content: center;
  -webkit-align-items: center;
	-webkit-box-align: center;
  -webkit-box-pack: center;
}

span {
  vertical-align: middle;
  font: 14px/1.5 helvetica neue, tahoma, arial, hiragino sans gb, microsoft yahei, sans-serif;
}